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A scientific infographic on right ventricular remodeling in pulmonary hypertension, detailing molecular pathways, sex differences, and therapeutic targets.

``` Create a comprehensive scientific summary figure for a review article on "Right Ventricular Remodeling in Pulmonary Hypertension: Multi-omics Insights". **Layout**: 2x3 grid poster-style infographic with central schematic of RV progression (Adaptive → Maladaptive → Failure) connecting all panels. **Panel 1 (Top Left) - Models Overview**: - Side-by-side silhouettes: Rat (MCT/SuHx/PAB), Pig (PVB/APS), Human RV tissue - Timeline showing progression: Normal → Compensated → Decompensated - Color code: Green (adaptive), Yellow (transition), Red (failure) **Panel 2 (Top Center) - Core Molecular Pathways**: - Network diagram with 5 main hubs connected by thickness-weighted arrows: 1. **ECM/Fibrosis** (↑ Collagens/NID1/CRTAC1) - Red/thickest 2. **Metabolic Shift** (↓FAO/↑Glycolysis/Ferroptosis) - Orange 3. **Mitochondrial** (↓OXPHOS/TCA/↑LCFA) - Purple 4. **Inflammation/Immune** (↑Cytokines/Complement) - Blue 5. **Novel Pathways** (Vesicle transport/Autophagy/EMT) - Green/dashed **Panel 3 (Top Right) - Sex Differences**: - Split male/female icons: Males (Androgen↑→mTOR/fibrosis), Females (Estrogen↑→FA protection) - Timeline: Males faster maladaptation trajectory **Panel 4 (Middle Left) - Omics Findings Heatmap**: - 4x4 grid heatmap (rows: proteomics/metabolomics/transcriptomics/MRI; columns: studies) - Color gradient: Blue (↓ in failure) → Red (↑ in failure) - Key markers labeled: PPARγ, TGF-β, RyR2, ferroptosis proteins **Panel 5 (Middle Right) - Therapeutic Targets**: - Target Ver mais

#scientific #medical #infographic #technical illustration

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